Endocrine Abstracts

Background: The relationship between cardiovascular (CV) diseases (CVD) and testosterone levels in men has not been completely clarified.Aim: To evaluate the association between testosterone levels and CV risk in subjects with erectile dysfunction (ED) and to verify whether their body mass index might (BMI) represents a possible confounder in testosterone-related CV stratification.Material and methods: A consecutive series of 2269 ...

Introduction: Despite their efficacy in the treatment of benign prostatic hyperplasia (BPH) the popularity of inhibitors of 5α-reductase (5ARIs) is limited by their association with adverse sexual side effects. However, the real impact of 5ARIs on sex hormones and sexual function is controversial.Aim: The aim of this study is to investigate the role of 5ARIs therapy on hormonal parameters and sexual function in men already complaining of sexual prob...

Introduction: Premature ejaculation (PE) and erectile dysfunction (ED) are considered pre-testicular causes of male subfertility. No previous study systematically evaluated the prevalence of ED and PE along with their possible correlations with clinical and colour-Doppler ultrasound (CDU) features in infertile men.Methods: Ejaculatory status, erectile function, prostatitis symptoms and psychopathological traits of 244 men complaining of couple infertilit...

Introduction: Prostatitis-like symptoms (PLS) may originate from the prostate or from pelvic or scrotal organs. The National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) is considered the gold-standard instrument to assess PLS severity. Although several studies previously investigated the impact of prostatitis, vesiculitis or epididymitis on semen parameters, only a few studies evaluated the correlations between PLS and scrotal or transrectal colour-Dopple...

Introduction: The disorders of orgasm/ejaculation include premature ejaculation, delayed ejaculation and perceived ejaculate volume reduction (PEVR). To explore the specific associations of PEVR in subjects with erectile dysfunction (ED).Methods: A consecutive series of 3141 subjects (mean age 51.6±13.1 years old) was studied. Among these, 71 have been excluded because they underwent prostate surgery. Different clinical and biochemical factors were ...

Introduction: Perceived reduced sleep-related erections (PR-SREs), along with erectile dysfunction (ED) and hypoactive sexual desire, have been recently recognized as the most important symptoms characterizing late onset hypogonadism in community-dwelling European men. However, the clinical correlates of PR-SREs have not been thoroughly investigated. The aim of this study is to evaluate the psychobiological correlates of PR-SREs in a large series of subjects consulting for ED....

Introduction: Although several studies have demonstrated that MetS is associated with a twofold increase in the risk of cardiovascular (CV) diseases, this risk does not appear to be greater than the sum of risks associated with each of its individual components. To determine the association of men with ED and individual components of MetS and their subsequent relationship to cardiovascular (CV) risk, and, more specifically whether the sum of the MetS components is greater than...

Introduction: We previously reported that in subjects consulting for sexual dysfunction lower PRL plasma levels were associated with worse lipid and glycemic profile, as well as with a higher prevalence of metabolic syndrome and arteriogenic erectile dysfunction (ED). To assess possible associations between PRL levels and incident major cardiovascular events (MACE) in subjects with ED.Methods: This is an observational prospective cohort study evaluating ...

Introduction: Obesity is an independent cardiovascular (CV) risk factor. Testosterone (T) is inversely related to body mass index (BMI) in males. There is substantial evidence suggesting that low T could play a role as a moderator of CV mortality in men, and so this study is designed to assess the possible interaction between T and obesity in predicting major cardiovascular events (MACE) in a sample of subjects with erectile dysfunction.Methods: This is ...

Introduction: Erectile dysfunction (ED) and mood depression are often associated and both are correlated with an increased risk of cardiovascular morbidity and mortality. The aim of the present study is to explore biological and clinical correlates of depressive symptomatology in a sample of men consulting for sexual dysfunction and to verify possible associations between depressive symptoms and incidence of major cardiovascular events (MACE).Methods: A ...